Crosstalk between Cu(i) and Zn(ii) homeostasis via Atx1 and cognate domains† †Electronic supplementary information (ESI) available: Materials and methods, a figure showing gel filtration data and a table containing crystallographic data collection and processing statistics. See DOI: 10.1039/c3cc42709aClick here for additional data file.
نویسندگان
چکیده
The copper metallochaperone Atx1 and the N-terminal metal-binding domain of a copper-transporting ATP-ase can form tight Zn(II)-mediated hetero-complexes in both cyanobacteria and humans. Copper and zinc homeostasis could be linked by metal binding to these CXXC-containing proteins.
منابع مشابه
Mixed valence mono- and hetero-metallic grid catenanes† †Electronic supplementary information (ESI) available: Details of the CSD database search, additional crystallographic information on 3–6 with relevant tables, EDS analysis and EDS plots. CCDC 1054509–1054512. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01851j Click here for additional data file. Click here for additional data file.
Here, we report on the multicomponent self-assembly and single crystal X-ray diffraction study of a series of three interlocked mixed valence monoand hetero-metallic [2]-catenanes made of [2 2] metallo-grids. They show unique structural features and highlight the essential roles of both the Cu(II)/Cu(I) pair and of the conformationally adaptable organic ligands for achieving catenation of grids.
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Department of Anatomy and Structural Center, Albert Einstein College of Medicine [email protected] Macromolecular Crystallography Laborat Biomedical Research Inc., Basic Research Pr Shemyakin-Ovchinnikov Institute of Bioo Sciences, Moscow 117997, Russian Federati Department of Molecular and Cellular Bi California 95616, USA Department of Biochemistry and Develo University of H...
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